EPA has denied a petition to remove Ethylene Glycol Monobutyl Ether (EGBE) from the list of chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA). Criteria for a Recommended Occupational Exposure Standard for Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether Acetate—DHHS (NIOSH) No. Pharmacol. However, more realistic assumptions based on the available data suggest that risk to aquatic organisms is low. The rates of excretion of the ¹⁴C-labeled parent compound and metabolites by different routes were measured, as well as the amount of ¹⁴C remaining in the carcass. Access scientific knowledge from anywhere. 2-Butoxyethanol (BE) is a massively produced glycol ether of which more than 230 million pounds was produced in the United States in 1983. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by Many of the lesions have been reported in single or small numbers of animals. Its potential for bioaccumulation is low. They are used in paints, lacquers, stains, inks and surface coatings, silk-screen printing, photographic and photo lithographic processes, for example, in the semiconductor industry, textile and leather finishing, production of food-contact plastics, and as an antiicing additive in hydraulic fluids and jet fuel. Polyethylene Glycol: Polyethylene glycol is a polyether compound, meaning that it has many ether groups. Decreased body weight gains and increased liver weights were also found. Levels of airborne 2-butoxyethanol in occupational settings are typically in the mg/m3 range. All animals are susceptible to ethylene glycol (EG) toxicity, but it is most common in dogs and cats. The EPA, A poly(dimethylsiloxane) type silicone oil containing gamma-mercaptopropyl groups was evaluated for acute toxicity. There were no treatment-related effects with respect to hematology, necropsy, or gestational parameters and no significant change in the incidence of malformations or variations (expressed as total, individual, external, visceral, or skeletal). 2019 Oct-Dec;10(4):184-189. doi: 10.4103/japtr.JAPTR_57_19. In rats, adverse effects on the central nervous system, kidneys, and liver occur at higher exposure concentrations than do haemolytic effects. Professional cleaners were found to be exposed to multiple airborne irritants at low concentrations, thus these substances should be considered in investigations of respiratory dysfunctions in the cleaning industry; especially in specialized cleaning tasks such as intensive floor cleaning. Toxicol Rep. 2020 Jun 23;7:779-787. doi: 10.1016/j.toxrep.2020.06.007. It is also used in metal and household cleaners. Early symptoms include intoxication, vomiting and abdominal pain. Indirect exposure of the general population to 2-butoxyethanol is most likely from inhalation and dermal absorption during the use of products containing the chemical. EGMEA is rapidly converted to EGME in the body and the two substances are equally toxic in animals. These 95% commercial antifreeze preparations are diluted ~50% with water when used in vehicle cooling systems. In a subsequent study, rats were exposed for 9 days (6 hr/day) to EGBE concentrations of 245, 86, 20, or 0 (control) ppm. 2016 Dec;36(12):1614-1621. doi: 10.1002/jat.3326. The estimated half-life of 2-butoxyethanol in water is approximately 1-4 weeks, and the chemical is likely readily biodegraded in aerobic soil and water. 2005 Mar 28;156(1):13-28. doi: 10.1016/j.toxlet.2003.08.010. Toxicity and death may occur after drinking even a small amount. 2-Butoxyethanol exists in the atmosphere almost entirely as a vapour; because the chemical has an atmospheric half-life of approximately 17 h, the risk for transport via the atmosphere should be small. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Transient eye irritation and barely perceptible skin irritation were among, We tried out the potential irritant and sensitizing effect of the main glycol ethers found in industrial and consumer products. Information on the peer review of this CICAD is presented in Appendix 2. Relatively little work has been done on the toxicity of organic arsenicals, especially the herbicide monosodium methanearsonate (MSMA). J Adv Pharm Technol Res. However, there were no gross or histopathologic lesions found to indicate impairment of the liver.  |  The no-effect vapor concentrations for maternal toxicity were 41.1 ppm for rabbits and 20.8 ppm for rats. This CICAD on 2-butoxyethanol was based upon reviews prepared by the National Institute for Occupational Safety and Health (NIOSH, 1990) and the Agency for Toxic Substances and Disease Registry (ATSDR, 1996). During 2003, the production of EGBE in the European Union was approximately 161,000 tonnes. Products because of its properties as a protector on 2-methoxyethanol-induced cardiac cell damage in mice effect exerted by and... Stained urine, and examined for external, visceral, and noncardiogenic pulmonary edema by... Disturbed hematopoiesis have been linked with exposure to ethylene glycol butyl ether ( 2-butoxyethanol ) ; CASRN 111-76-2 clinical. 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